98% Magnolol Pure Natural Magnolia Bark Extract 80 Mesh

Product Description

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What is Magnolia bark extract?

More than 200 types of magnolia trees exist worldwide. One type — Magnolia officinalis — is commonly called the houpo magnolia, or sometimes simply “magnolia bark.” The houpo magnolia tree is native to China, where it has been used for thousands of years as a supplement in traditional Chinese medicine. Typically, magnolia bark is bark of the houpo magnolia tree that has been stripped away from it branches and stems to make supplements. The leaves and flowers from the tree are sometimes used as well. The bark is particularly rich in two neolignans that are believed to be responsible for its medicinal properties — magnolol and honokiol. Neolignans are a type of polyphenol micronutrient in plants. Polyphenols are highly valued for their antioxidant levels and believed to offer many health benefits. Some of the conditions that magnolia bark has traditionally been used to treat include asthma, anxiety, depression, stomach disorders, and inflammation.

Magnolia bark extract (MBE) is a natural product used as an anti-inflammatory, anti-platelet, and chemo-preventive agent. Here, we investigate the effects of MBE on the self-perceived freshness of breath evaluated in ten human volunteers, who chewed gum with and without MBE added, as a functional food. Furthermore, the effects of exposing oral bacteria to MBE on cell-surface hydrophobicity were determined and bactericidal effects of MBE in human saliva were assessed. Volunteers perceived freshness of breath similar directly after chewing a gum with or without MBE added, but 60 min after chewing MBE gum, freshness was perceived significantly better. Also, cell-surface hydrophobicity of Gram-negative, but not of Gram-positive bacteria, increased dose-responsively after exposure to MBE, while spiking of saliva with MBE did not affect bacterial viability. Taken together, MBE gum improves self-perceived freshness of breath likely due to an increase in cell-surface hydrophobicity of Gram-negative bacteria, instead of a bactericidal mechanism.

Magnolol is an active substance extracted from the dried root bark of Magnolia officinalis Rehd. EtWils. It has special and lasting muscle relaxation and strong antibacterial action, and can inhibit platelet aggregation. Clinical mainly used as antibacterial, antifungal drugs. The product should be sealed away from light and stored in a dry, cool and well-ventilated environment.

Magnolol inhibits NF-κB and MAPK signaling pathways and apoptosis and activates NRF2/KEAP1 and PI3K/Akt/FOXO signaling pathways. Stimulators, such as LPS and TNFα, induce activation of NF-κB and MAPK signaling pathways. Magnolol shows inhibitory effects on NF-κB and MAPK signaling pathways, inhibits mitochondrial apoptosis, but upregulates the activities of NRF2/KEAP1 and PI3K/Akt/FOXO signaling pathways.

Benefits:

May protect against the effects of oxidative stress and inflammation

Oxidative stress and subsequent inflammation are one cause of chronic conditions like diabetes, cancer, heart disease, and neurodegenerative diseases like Alzheimer’s. Oxidative stress also appears to play a significant role in many changes in the body and mind that accompany aging. Polyphenols, such as those found in magnolia bark, have been suggested as a potential therapy to combat the side effects of oxidative stress and inflammation. Based on research in mice, some scientists believe that honokiol may help combat aging by increasing antioxidant enzymes and decreasing levels of methane dicarboxylic aldehyde. In research, changes in levels of methane dicarboxylic aldehyde are often interpreted as a sign of antioxidant activity. Research on honokiol has found that it can reduce inflammation in the brain and spinal cord specifically, partly due to its ability to cross the blood-brain barrier. This suggests that it has potential as a therapeutic agent for neurodegenerative diseases like Alzheimer’s. Moreover, oxidative stress is widely believed to contribute to diabetes and its related complications. In a 2016 review, magnolia bark was found to improve high blood sugar levels and diabetic complications in animals. Nevertheless, additional research in humans is needed.

May have anticancer properties

Various studies on honokiol support the use of this polyphenol in magnolia bark as a therapy for cancer treatment and prevention. One way in which honokiol may combat cancer is by helping regulate cell signaling pathways. Given that cancer is a disease characterized by abnormal cell division and growth, the ability to regulate cellular pathways is beneficial. A 2019 review study found that honokiol has shown potential to prevent tumor growth in the brain, breast, colon, liver, and skin, among other organs.

Furthermore, honokiol may not only have anticancer properties itself but also help increase the effectiveness of other anticancer and radiation drug therapies. Though more rigorous human studies are needed, the polyphenol shows promise as an anticancer therapy in humans. What’s more, magnolol likewise appears to have anticancer properties. Similar to honokiol, studies in animals have shown that magnolol may help control and suppress tumor growth in various organs. Additionally, a test-tube study found that magnolol inhibited the growth of lung cancer cells. Yet again, clinical studies in humans need to be conducted.

May relieve stress and anxiety

As mentioned, magnolia bark extract appears to have protective effects against many neurological conditions. This not only includes brain disorders like Alzheimer’s disease but also conditions like stress, anxiety, mood disorders, and depression. A study in 40 women ages 20–50 found that taking 250 mg of magnolia and phellodendron bark extract 3 times a day resulted in greater relief of short-term and temporary anxiety than taking a placebo. A second study of the same magnolia and phellodendron bark extract in 56 adults observed that consuming 500 mg of the extract per day resulted in significantly lower cortisol levels and improved mood. Cortisol is the primary stress hormone in your body. When cortisol levels decrease, it suggests that overall stress has also decreased. However, the supplement used in these studies contained compounds other than magnolia bark. Therefore, the effects cannot be credited to the tree bark alone. Lastly, a study in rodents noted that a mixture of honokiol and magnolol caused antidepressant-like effects, including improvements in serotonin levels in the brain and reductions in corticosterone levels in the blood. Corticosterone and serotonin each play a role in regulating anxiety, mood, and depression.

May improve sleep

The polyphenols in magnolia bark — honokiol and magnolol — have been found to help induce and improve sleep. Therefore, magnolia bark could be used as a remedy for insomnia or simply to promote better sleep overall. A study in mice found a magnolol dose of 2.3–0.9 mg per pound (5–25 mg per kg) of body weight significantly decreased sleep latency, or the amount of time it takes to fall asleep. The same study observed that the same dose increased REM (rapid eye movement) and non-REM sleep. Additionally, the magnolol appeared to increase the number of times the mice woke up during sleep but decrease the length of time they were awake. A second study in mice observed similar outcomes after administering honokiol, which also decreased the amount of time it took the mice to fall asleep and transition into non-REM sleep.

Magnolia bark’s effects on sleep appear to be closely connected to the activity of the GABA(A) receptors in the central nervous system. This makes sense, as it’s known that GABA(A) receptor activity is closely associated with sleep.

May improve symptoms of menopause

Some of the benefits of magnolia bark, such as improved sleep and mood, could be especially beneficial for women during menopause. A 24-week study in 89 menopausal women experiencing symptoms of sleep and mood alterations were given a supplement containing 60 mg of magnolia bark extract and 50 mg of magnesium daily. The women experienced significant improvements in insomnia, anxiety, mood, and irritability. Still, magnolia bark extract was not the only compound examined in this study. Thus, it cannot be said with certainty that the effects were due solely to the magnolia bark. A similar study in more than 600 menopausal women found that consuming a magnolia bark supplement daily for 12 weeks relieved symptoms of insomnia, irritability, and anxiety. Another study in 180 menopausal women determined that a supplement containing magnolia bark, soy isoflavones, and lactobacilli more effectively reduced the severity and frequency of hot flashes than a supplement containing the soy isoflavones alone. Again, note that magnolia bark extract was not the only supplement given in this study. Nevertheless, magnolia bark appears to be a safe therapy that may help treat menopause symptoms.

Application

1. As the product of anti-inflammatory, antibacterial, antioxidant and anti-tumor drug, it is widely used in the fields of medicine and health products;
2. As a strong antioxidant, it is widely used in cosmetics industry-Magnolol is powerful antioxidant in cardiovascular diseases.