Ubiquinone 10% Water Soluble Coenzyme Q10 Powder CAS 1077-28-7
Contact Person : Jane Jiang
Phone Number : 86-13572180216
WhatsApp : +8613572180216
|Minimum Order Quantity :||25KG||Packaging Details :||Sample：1kg/bag with Polyethylene bag. Orders: Professional Drum with Net Weight 25kg|
|Delivery Time :||7-15 days||Payment Terms :||L/C, T/T|
|Supply Ability :||1000kg per month|
|Place of Origin:||CHINA||Brand Name:||HONGDA|
|Form:||Powder||Appearance:||Orange Fine Powder|
|Product Name:||Coenzyme Q10||Application:||Health-care Products, Food Field, Cosmetic Field|
|Specification:||98% Coenzyme Q10||Shelf Life:||2 Years|
Phytochemistry 98% Coenzyme Q10,
Anti Aging Coenzyme Q10,
CAS 303-98-0 Coenzyme Q10
|Product name:||98% Coenzyme Q10|
|Color:||Orange Fine Powder|
|Particle Size:||100% pass 80 mesh|
|Loss on drying:||≤5.00%|
|Acid insoluble Ash:||≤5.0%|
|Heavy metals(as Pb):||≤10ppm|
|Total microbacterial count:||NMT10000cfu/g|
|Total Yeast & Mold:||NMT1000cfu/g|
What is Coenzyme Q10?
In fact, CoQ10 is a substance that occurs naturally in the body, with the highest levels found in the heart, liver, kidneys and pancreas. Due to the important function of coenzyme Q10 in the human body, the content of this substance in the human body, especially in some organs, is reduced in some special physiological or disease states.
Coenzyme Q10 is often sold as a "dietary supplement" in countries such as the United States, and so far, researchers have focused on whether coenzyme Q10 supplements are beneficial to health.
It is worth noting that the "China Heart Failure Diagnosis and Treatment Guidelines 2018" and "Chinese Expert Consensus on the Diagnosis and Treatment of Fulminant Myocarditis in Adults" officially recommend coenzyme Q10 as an adjuvant drug treatment method, which can improve the myocardial energy metabolism of patients, thereby improving cardiac function.
Coenzyme Q10, also known as ubiquitin ketone, has a simple structure, is ubiquitous in animals and most bacteria, and belongs to the coenzyme family.
In the human body, the most common form is coenzyme Q10 or ubiquitin 10, which is fat-soluble, similar to vitamins, and can be synthesized by the human body in small amounts. substance.
In addition to red blood cells, most tissue cells and 95% of energy in the body require aerobic metabolism for energy. Therefore, those organs with the highest energy requirements, such as the heart, liver, kidney and pancreas, have the highest concentration and content of coenzyme Q10.
In addition, CoQ10 is also an antioxidant with antioxidant and anti-inflammatory properties.
Recently, the National Institutes of Health's Office of Dietary Supplements and the Library Service released the results of a dismal review of research on CoQ10.
There is only one function supported by "strong scientific evidence": severe abnormal metabolism or mitochondrial dysfunction may lead to insufficient synthesis of coenzyme Q10 in the body. By supplementing coenzyme Q10, related vitamins and minerals, the body's functional status can be improved.
The function of coenzyme Q10
1. Heart disease
(1) Heart failure
The Q-SYMBIO study showed that the incidence of major adverse cardiovascular events, cardiovascular mortality and all-cause mortality in patients taking coenzyme Q10 were lower, and the NYHA cardiac function class could be improved.
"China Heart Failure Diagnosis and Treatment Guidelines 2018" analysis pointed out that myocardial cell energy metabolism disorder plays a certain role in the occurrence and development of heart failure. For the drug treatment of chronic heart failure with reduced ejection fraction (HFrEF), the use of improving myocardial energy metabolism Drugs such as trimetazidine and coenzyme Q10 can improve myocardial cell energy metabolism, symptoms and cardiac function, and improve quality of life.
The "Chinese Expert Consensus on the Diagnosis and Treatment of Fulminant Myocarditis in Adults" pointed out that all patients with fulminant myocarditis should be given general symptomatic and supportive treatment, and coenzyme Q10 and other treatments to improve myocardial energy metabolism and cardiac function are actively recommended.
Coenzyme Q10 is safe to take for a long time, without accumulation and toxic side effects. Currently, the recommended dosage is 20-100 mg, 3 times/d.
Despite these positive findings, further research is needed on how to identify patients who would benefit from coenzyme Q10 before inclusion of coenzyme Q10 in guided drug therapy.
(3) Coronary heart disease
Studies have found that coenzyme Q10 content less than 60% can lead to palpitation, chest tightness, fatigue and weakness, less than 40% can lead to myocardial infarction, myocardial ischemia, coronary heart disease, less than 25% of the heart will stop beating or even sudden death.
However, current evidence does not support the routine use of coenzyme Q10 in patients with coronary heart disease, and more research is necessary to fully define the benefit of coenzyme Q10 in patients with coronary heart disease before including coenzyme Q10 in guiding drug therapy.
(4) Other heart-related effects
The effect of coenzyme Q10 on specific cardiovascular risk factors such as blood pressure, dyslipidemia and glycemic control was not significant;
There is little evidence that coenzyme Q10 can reduce the risk of certain complications of heart surgery and can be taken before surgery;
Has no value in treating cancer, but it can reduce the risk of heart damage from a cancer chemotherapy drug;
There is no positive effect on arrhythmia, especially malignant or potentially malignant arrhythmias such as premature ventricular contractions, atrial fibrillation, and ventricular tachycardia, and the patient benefits are not significant.
2. Nervous system diseases
Coenzyme Q10 may treat and prevent migraines.
The study found that coenzyme Q10 deficiency is common in people with migraine, and coenzyme Q10 supplementation can reduce the incidence of coenzyme Q10 by three times compared with patients not taking coenzyme Q10. A larger study found that 1,550 patients with low coenzyme Q10 levels experienced less pain and fewer attacks after coenzyme Q10 treatment, so coenzyme Q10 appears to not only treat migraine but also prevent migraine headaches The Academy and the American Headache Association recommend it for the prevention and treatment of migraine, based on limited evidence.
(2) Parkinson's disease
Coenzyme Q10 is not helpful in relieving symptoms in Parkinson's patients.
A large U.S. study showed that even at higher-than-usual doses, coenzyme Q10 did not improve symptoms in people with early-stage Parkinson's disease.
A 2017 review of this and several other smaller studies concluded that coenzyme Q10 was not significantly helpful in relieving Parkinson's symptoms and slowing the progression of diseases such as ALS, Down's syndrome and Huntington's disease.
(3) Multiple system atrophy
Multiple system atrophy is a neurological disorder characterized by orthostatic hypotension, Parkinson's syndrome, and cerebellar signs. High-dose coenzyme Q10 may be beneficial in early-stage patients and may improve orthostatic hypotension.
Early research suggests that high doses of coenzyme Q10 may benefit patients in the early stages of this progressive disease of the motor nervous system. Mutations in C0Q2, an enzyme involved in coenzyme Q10 synthase, are associated with familial and sporadic cases of multiple system atrophy.
A study found that coenzyme Q10 can improve orthostatic hypotension. This study used a non-randomized method. Daily coenzyme Q10 (257 ± 37 mg) treatment for 10 ± 3 months, before starting coenzyme Q10, the patient's systolic blood pressure decreased when standing from a sitting position. 30 ± 4 mmHg, and systolic blood pressure decreased by 7 ± 5 mmHg after coenzyme Q10 treatment (paired t-test, P = 0.007).
3. Other functions
(1) Regarding the side effects of statin-related muscle symptoms, although the results of each study are different, the overall scientific evidence does not support the view that coenzyme Q10 can reduce statin-related muscle symptoms (SAMS: Statin-Associated Muscle Symptoms);
The latest US cholesterol guidelines in 2018 and the Taiwan Society of Lipid and Atherosclerosis Statin Intolerance Expert Consensus Statement "Statin Safety and Side Effects" section pointed out that muscle enzyme level testing is not routinely recommended during statin use (COR: III, LOE: BR), the effect of coenzyme Q10 on muscle symptoms and myopathy is uncertain, and whether it can improve statin-related muscle symptoms is uncertain (COR: III, LOE: C-LD);
(2) One study investigated the effect of coenzyme Q10 on physical activity, supplementing 1200 mg of coenzyme Q10 daily for 60 days reduced oxidative stress in muscles after exercise, the possible mechanism is that coenzyme Q10 is involved in energy production, and coenzyme Q10 supplementation can reduce oxidative stress in muscles after exercise. Improve physical condition and performance by reducing oxidative stress in cells and improving mitochondrial function, reducing fatigue;
(3) Likewise, the antioxidant properties of CoQ10 help and even possibly reverse age-related declines in egg and sperm quality and quantity, improve sperm quality, activity and concentration, and improve reproductive performance;
1. Coenzyme Q10 is used in cosmetic field;
2. Coenzyme Q10 is used in healthcare products;
3. Coenzyme Q10 is used in dietary supplements.