99% Beta NMN Bulk Powder Nicotinamide Mononucleotide Food Grade

Product Description

Food Grade Beta NMN Nicotinamide Mononucleotide Pure 99% NMN Powder

Basic Information
Product Name	Beta Nicotinamide Mononucleotide Powder
Appearance	Powder
Odor &Taste	Characteristic
Test Method	HPLC
Specification	99%
NMN	CAS NO.	1094-61-7
	Molecular Formula	C11H15N2O8P
	Molecular Weight	334.22

 

What is NMN?

NMN (nicotinamide mononucleotide) is one of the derivatives of vitamin B3 (nicotinic acid) and an intermediate product of NAD+ biosynthesis. It is composed of phosphate groups and ribose and nicotinamide. Bioactive Nucleotides Formed by Nucleoside Reactions

 

Generally, it exists in two synonymous forms, alpha, and beta. The beta isomer is the active form with a molecular weight of 334.221 g/mol.

 

NMN is present in small amounts in various natural foods such as vegetables, fruits, and meat.

 

Vegetables such as cauliflower, and cabbage contain 0.25 to 1.12 and 0 to 0.90 mg of NMN per 100g, fruits such as avocado, and tomato contain 0.36 to 1.60 and 0.26 to 0.30 mg of NMN per 100g, and beef contains 0.06 to 0.42 per 100g mg of NMN.

What is NAD+?

NAD+ (nicotinamide adenine dinucleotide) is an important coenzyme that exists in eukaryotic cells and is required for more than 500 enzymatic reactions. It plays a key role in a variety of biological processes, including metabolism, aging, mitochondrial function, DNA repair, and gene expression.

 

NAD+ deficiency is closely associated with multiple pathophysiological mechanisms, including type 2 diabetes, obesity, heart failure, Alzheimer's disease, and cerebral ischemia.

 

NAD+ levels in multiple organs gradually decline with age, which can accelerate the development of age-related diseases. Therefore, raising NAD+ is considered a possible response to disease and is critical to human health and longevity.

 

What are the empirical powers (benefits) of NMN?

1. Beneficial for the physical function of the elderly

Aging is associated with decreased muscle strength and fitness, which exacerbates the burden of daily workability, increases the risk of falls and adverse health outcomes

 

By 2030, the elderly population is projected to outnumber the number of children under the age of 10 (1.41 billion, 1.35 billion) According to projections for 2050, the number of people aged 60 and over will exceed that of teenagers and young adults aged 10 to 24 (2.1 billion people, 2 billion people)

 

Performance indicators are useful tools for predicting functional decline and risk of death and have become an important part of geriatric assessment

 

A randomized, double-blind, placebo-controlled study (12 weeks in 108 participants over the age of 65) noted that supplementation with NMN (250 mg daily) improved lower extremity function and reduced drowsiness.

 

2. Improve aerobic endurance

Habitual exercise is an effective factor in weight control for people of all ages, and it has many other positive effects, including preventing metabolic and cardiovascular disease and promoting mental health.

 

Literature analysis (Meta-Analyses in sedentary healthy adults) confirmed that running helps reduce body mass index, body fat, resting heart rate, and triglycerides, and increases VO2max and high-density Lipoprotein cholesterol, especially with long-term regular training.

 

A randomized, double-blind, placebo-controlled clinical trial (6-week duration of 48 healthy amateur runners) with subjects divided into four groups: a low-dose group (daily dose of NMN 300 mg), a medium-dose group ( NMN daily dose 600mg), high dose group (NMN daily dose 1200mg) and control group.

 

The results indicated that compared with the control group, the oxygen uptake, the percentage of maximal oxygen uptake, and the first and second ventilation thresholds of the NMN medium and high dose groups all increased to a higher degree.

 

3. Improve skeletal muscle metabolism

Skeletal muscle accounts for 40% of total body weight and consists of slow-twitch and fast-twitch fiber types that differ in contractile protein composition, oxidative capacity, and matrix preference for ATP production.

 

Slow-twitch fibers exhibit low fatigue, high oxidative capacity, and a preference for fatty acids as substrates for ATP production. Fast-twitch fibers have higher fatigue, higher contractile strength, lower oxidative capacity, and prefer glucose as a substrate for ATP production through anaerobic glycolysis.

 

A randomized, placebo-controlled, double-blind trial (10 weeks in overweight or obese prediabetic women) showed that NMN (250 mg daily) increased muscle insulin sensitivity, muscle insulin signaling, and muscle remodeling.

 

4. Beneficial for liver fibrosis

Liver fibrosis is a reaction caused by chronic liver damage such as alcohol intake, viral hepatitis (hepatitis B and C), autoimmune hepatitis, nonalcoholic fatty liver disease, and cholestatic liver disease.

 

The structure of the liver is destroyed by the presence of fibrous scars, which leads to loss of liver cells and dysfunction of normal liver function, eventually leading to liver failure.

 

Liver fibrosis is a reversible process, and as long as the liver is not in the advanced stage of cirrhosis, removal of the fibrotic response helps fibrosis to resolve.

 

An animal study pointed out that NMN supplementation inhibited the activation of hepatic stellate cells in mice and prevented liver fibrosis, providing a new opportunity for the development of liver fibrosis therapy.

 

5. Anti-aging

Telomeres are specific DNA protein structures found at the ends of each chromosome that protect the genome from nucleolytic degradation, unwanted recombination, repair, and interchromosomal fusion.

 

Therefore, telomeres play a crucial role in preserving the information in our genome. As a normal cellular process, a small portion of telomeric DNA is lost with each cell division.

 

When telomere length reaches a critical value, cells age or die. Therefore, telomere length can serve as a biological clock to determine the lifespan of a cell and an organism.

 

An animal study indicated that the NAD+ precursor nicotinamide mononucleotide (NMN) maintains telomere length, inhibits the DNA damage response, and improves mitochondrial function.

 

6. Good for blood sugar control

Diabetes is a common chronic disease characterized by hyperglycemia. It has two types, which are summarized as type 1 diabetes and type 2 diabetes.

 

Type 1 diabetes is an autoimmune disease with absolute insulin deficiency that develops in young adults. Type 2 diabetes is characterized by insulin resistance, hyperinsulinemia, and beta-cell failure

 

Diabetes and poor control are associated with microvascular (retinopathy and nephropathy), macrovascular, and nonvascular (neuropathy) complications.

 

An animal study pointed out that nicotinamide mononucleotide (NMN) can enhance hepatic insulin sensitivity by partially initiating SIRT1, restoring gene expression related to oxidative stress, inflammatory response, and circadian rhythm, and helping improve glucose intolerance.

 

7. Beneficial for Alzheimer's

Alzheimer's disease, the most common form of dementia (affecting tens of millions of people worldwide), is characterized by synaptic loss and neuronal death in brain regions critical for learning, memory, and emotional control and progressive cognitive impairment.

 

Accumulation of two self-aggregating proteins, including extracellular amyloid plaques and intracellular neurofibrillary tangles, is a diagnostic feature of Alzheimer's disease

 

A study in a rat model of Alzheimer's disease indicated that NMN treatment improved neuronal survival, improved energy metabolism, and reduced reactive oxygen species accumulation.