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HPLC Method Reynoutria Japonica Houtt Extract Emodin 50% Pure Natural Polygonum Cuspidatum Extract

Minimum Order Quantity : 25KG Packaging Details : Sample:1kg/bag with Polyethylene bag. Orders: Professional Drum with Net Weight 25kg
Delivery Time : 7-15 days Payment Terms : L/C, T/T, Western Union
Supply Ability : 1000kg per month
Place of Origin: CHINA Brand Name: HONGDA
Certification: ISO22000/KOSHER/HALAL/BRC/SC/ORGANIC Model Number: HD-040

Detail Information

Grade: Food Grade Packaging: Drum
Form: Powder Type: Herb Extract
Part: Root Appearance: Brown Yellow Fine Powder
Product Name: Reynoutria Japonica Houtt Extract Test Method: HPLC
Application: Health-care Products, Food Supplement,Cosmetics Field,Pharmaceutical Field Specification: Emodin 50%
Shelf Life: 2 Years Color: Brown Yellow
Latin Name: Reynoutria Japonica Houtt Active Ingredient: Resveratrol;Emodin
Function: Anti-inflammatory;Antimicrobial;Antioxidant;antiseptic

Product Description

                                Quick Details

Product name: Reynoutria japonica Houtt extract
Latin name: Reynoutria japonica Houtt
Part Used: Root
TEST METHOD: HPLC
Color: Brown Yellow Fine Powder
Odor: Characteristic
density: 0.5-0.7g/ml
Particle Size: 100% pass 80 mesh
Loss on drying: ≤5.00%
Acid insoluble Ash: ≤5.0%
Heavy metals(as Pb): ≤10ppm
Lead(Pb): ≤2ppm
Arsenic (As): ≤2ppm
Residual Pesticide: Negative
Total microbacterial count: NMT10000cfu/g
Total Yeast & Mold: NMT1000cfu/g
Salmonella: Negative
E.Coli. Negative

 

Product description:

HPLC Method Reynoutria Japonica Houtt Extract Emodin 50% Pure Natural Polygonum Cuspidatum Extract 0HPLC Method Reynoutria Japonica Houtt Extract Emodin 50% Pure Natural Polygonum Cuspidatum Extract 1HPLC Method Reynoutria Japonica Houtt Extract Emodin 50% Pure Natural Polygonum Cuspidatum Extract 2

P. cuspidatum is a perennial plant growing to approximately 2 m tall. It has mucous hollow stems with reddish purple spots and ovate/elliptical deciduous leaves (5 to 12 cm by 4 to 9 cm). The male and female flowers occur on separate plants, and the fruits are black/brown, shiny, and ovoid. The plant is native to eastern Asia, including Japan, China, and Korea. It is cultivated in those countries and in the US, and is propagated by seeds or the root. Synonyms include Pleuropterus cuspidatus (Siebold & Zucc.) Moldenke, Fallopia japonica (Houtt.) Ronse Decr., Pleuropterus zuccarinii (Small) Small, Polygonum cuspidatum Siebold & Zucc. var. compactum (Hook. f.) L.H. Bailey, and Reynoutria japonica Houtt.

Huzhang (Japanese Knotweed) has been used in traditional Chinese medicine as well as in Japan and Korea for many years. Although used for various applications, few clinical studies validate claims and guidance regarding dosing or safety is limited.

At least 100 prescriptions using the root exist in the Pharmacopoeia of the People's Republic of China to treat bronchitis and cough, gonorrhea, inflammation, infection, jaundice, hyperlipidemia and hypertension, menopausal symptoms and amenorrhea, and skin burns. The root is used extensively in traditional medicine in China, Japan, and Korea, and the young plant parts are eaten as a vegetable. P. cuspidatum is a primary source of resveratrol, which is widely available in the United States as a botanical dietary supplement.

 

Emodin is a natural compound extracted from Chinese herbs such as polygonum cuspidatum, which has anti-inflammatory, antiviral, anti-tumor and other pharmacological effects. Emodin is mainly used for anti-inflammatory, anti-mutation, anti-corrosion, anti-cancer (chest), anti-ulcer, anti-virus, cathartic, gonadotropin, anti-suppression of epidemic force, insecticide, laxative, spasmolysis, hemostatic agent.

 

 

Chemistry

Volatile essential oils are described for the leaves, but the roots are the main plant part used traditionally. Major constituent chemicals include quinines (eg, anthraquinone, naphthoquinone, phylloquinone) and emodin-type anthroquinones, stilbenes (eg, resveratrol, piceatannol polydatin), flavonoids (eg, quercetin, catechin, rutin), coumarins, lignans, and other compounds.

Emodin and phsycion demonstrate anti-inflammatory effects.Shen 2011 The stilbene content, including resveratrol, resveratroloside, polydatin, and piceatannol, are responsible for observed antioxidant activity.

Methods of identification have been published, including high-performance liquid chromatography and thin-layer chromatography, which are based on the content of emodin and polydatin (minimum concentrations of 0.6% and 0.15%, respectively, per the Chinese pharmacopoeia). Chemical composition varies seasonally and with harvest time.

 

Uses and Pharmacology

Anti-inflammatory effects

Limited clinical studies have been conducted. A study among healthy volunteers found a decreased expression of modulators of inflammation in mononuclear cells following 6 weeks of P. cuspidatum extract daily containing resveratrol 40 mg.Ghanim 2010 A small study (N = 20) found decreased plasma TNF-alpha and IL-6 versus placebo.

 

Antimicrobial activity

In vitro studies have shown broad antibacterial and antifungal activity of P. cuspidatum extracts.

Antioxidant effects

Studies in rats and mice have shown antioxidant properties of P. cuspidatum that are generally attributed to the chemical constituents of resveratrol, polydatin, piceatannol, and anthraquinones and stilbenes. Carbon tetrachloride–induced liver injury and induced acute cerebral ischemia were reduced by oral extracts of P. cuspidatum. In models of vascular dementia and Parkinson disease in rats, P. cuspidatum extract and polydatin administered orally resulted in improved cognitive and behavioral measures and increased antioxidant capacity in the relevant tissues.

 

Cancer

In vitro studies using oral, lung, and prostate cancer cells, and in hepatocarcinoma, glioma, and leukemia have been conducted. Ethanol, methanol and aqueous P. cuspidatum extracts show pro-apoptotic activity and inhibition of angiogenesis, as well as direct cytotoxicity.

Hyperlipidemia

Studies conducted in the 1980s and 1990s in rodent models of hyperlipidemia showed decreased total cholesterol, as well as decreased triglycerides and low-density lipoprotein.

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