TLC Method Honeysuckle Flower Extract Herb Cosmetic Raw Material

Product Description

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Product description:

This herb is the flower buds of Lonicera japonica Thunb., or Lonicera hypoglauca Miq., or Lonicera confusa DC, or Lonicera dasystyla Rehd. (family Cap- rifoliaceae), or together with their newly-burst flowers, which are mainly produced in the provinces of Henan and Shandong. The flower buds are collected in early summer, dried in sunlight or in shade, and used unprepared.

Honeysuckle is a large genus, Lonicera, of more than 150 species of evergreen or deciduous shrubs or vines in the honeysuckle family, Caprifoliaceae, that are widespread in the Northern Hemisphere. Species of honeysuckle are valued for their tubular and often fragrant flowers.

Honeysuckle has been used in the treatment of influenza virus infection for thousands of years in China. However, its main active components and the functional mechanisms remain to be elucidated. Here, four honeysuckle extracts, including acids extract, flavonoids extract, total extract and acids-flavonoids mixture, were prepared to clarify the main active antiviral components. The cytopathic effect reduction assay showed that all the four extracts inhibited the replication of influenza viruses H1N1, H3N2 and the oseltamivir-resistant mutant strain H1N1-H275Y. The acids-flavonoids mixture had the strongest inhibitory effects in vitro with EC₅₀ values of 3.8, 4.1, and > 20 μg/mL against H1N1, H3N2 and H1N1-H275Y, respectively, showing competitive antiviral activity with oseltamivir and ribavirin. Honeysuckle acids extract also showed the most significant antiviral activity in vivo. Oral administration of the acids extract at a dosage of 600 mg/kg/d effectively alleviated viral pneumonia, maintained body weight and improved the survival rate to 30% of the mice infected with a lethal dose of H1N1. The results of time-of-drug addition experiment and neuraminidase (NA) inhibition assay showed that honeysuckle extracts had a broad-spectrum inhibitory effect against influenza virus NAs. The flavonoid extract showed the strongest inhibitory effect on the NA of influenza virus H7N9 with an IC₅₀ of 24.7 μg/mL. These results suggested that these extracts might exert their antiviral activity by suppressing the release of influenza viruses. Briefly, our findings demonstrate that acids and flavonoids extracts of honeysuckle are the major antiviral active components, and the acids extract has the potential to be developed into an antiviral agent against influenza virus, especially for oseltamivir-resistant viruses.

Function:

1. Honeysuckle Bud and Flower Extract is good for kidney.
2. Honeysuckle Bud and Flower Extract has wide anti-virus, anti-bacteria effect.
3. Honeysuckle Bud and Flower Extract has relatively lower toxicity and side-effects.
4. Honeysuckle Bud and Flower Extract has anti-hypertensive effect, anti-tumor effect.
5. Honeysuckle Bud and Flower Extract can be used as anti-infectious active ingredient.

Application:

1. Applied in food field

2. Applied in health product and functional food field

3. Applied in cosmetics field