7% Glycyrrhizic Acid Liquoric Root Pure Plant Extract CAS 1405-86-3

Product Description

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Product description:

Licorice is a perennial herb, 30 to 70 cm tall, with erect stems and cylindrical roots, 3-4 cm in diameter, 5-6 cm in giant ones, and more than 3 to 4 meters in height. Singular pinnately compound leaves; In summer, purple sphenoid flowers, racemes axillary, flowers dense, 5 -- 12 cm long, 1.5 -- 2.2 cm long. Pod linear oblong, 0.6 -- 0.8 cm wide, curved into a sickle or ring, with brown glandular spines.

Licorice is distributed in north China, northeast China, northwest China and Inner Mongolia, mainly growing in arid desert steppe.

The dry root and underground rhizoid of glycyrrhiza glycyrrhiza are clinically used in traditional Chinese medicine for nourishing and relieving, neutralizing strong drugs, detoxifying, relieving pain, relieving spasmolysis, correcting taste, relieving cough and relieving phlegm, etc. It can also be used for the adjuvant treatment of chronic pharyngitis. It is often used as an adjuvant in prescriptions.

In Traditional Chinese medicine, licorice has the pharmacological effects of detoxification, expectorant, pain relief, spasmolysis and anti-cancer. In Traditional Chinese medicine, licorice invigorates the spleen and replenishes qi, nourishing cough and moistening lung, detoxifying and mediating baiyao. Clinical application can be divided into "raw use" and "honey processing" (processed glycyrrhiza glycyrrhiza). Raw indications and indications for sore throat, sore and gangrenous ulcer, gastrointestinal ulcer and antidote poison, food poisoning, etc.

Glycyrrhizic acid

Glycyrrhizic acid is extracted from the root of the licorice plant; Glycyrrhiza glabra. It is a triterpene glycoside with glycyrrhetinic acid that possesses a wide range of pharmacological and biological activities. When extracted from the plant, it can be obtained in the form of ammonium glycyrrhizin and mono-ammonium glycyrrhizin. Glycyrrhizic acid has been developed in Japan and China as a hepatoprotective drug in cases of chronic hepatitis. From January 2014, glycyrrhizic acid as part of the licorice extract was approved by the FDA as an existing food sweetener. It was approved by Health Canada to be used in over-the-counter products but all the products are currently on the status canceled post marketed.

Glycyrrhizin is a saponin-like compound that provides the main sweet flavor for Glycyrrhiza glabra (licorice), with potential immunomodulating, anti-inflammatory, hepato- and neuro-protective, and antineoplastic activities. Glycyrrhizin modulates certain enzymes involved in inflammation and oxidative stress, and downregulates certain pro-inflammatory mediators, thereby protecting against inflammation- and reactive oxygen species (ROS)-induced damage. Glycerrhizin may also suppress the growth of susceptible tumor cells.

A widely used anti-inflammatory agent isolated from the licorice root. It is metabolized to GLYCYRRHETINIC ACID, which inhibits 11-BETA-HYDROXYSTEROID DEHYDROGENASES and other enzymes involved in the metabolism of CORTICO. Therefore, glycyrrhizic acid, which is the main and sweet component of licorice, has been investigated for its ability to cause hypermineralocorticoidism with sodium retention and potassium loss, edema, increased blood pressure, as well as depression of the renin-angiotensin-aldosterone system.

Benefits:

May aid skin conditions

Licorice root contains over 300 compounds, some of which demonstrate potent anti-inflammatory, antibacterial, and antiviral effects. In particular, animal and test-tube studies link glycyrrhizin to anti-inflammatory and antimicrobial benefits. As a result, licorice root extract is used to treat a variety of skin conditions, including acne and eczema.

In a 2-week study in 60 adults, applying a topical gel containing licorice root extract significantly improved eczema.

Though topical licorice gels have also been used to treat acne, research on its effectiveness is mixed and quite limited.

May reduce acid reflux and indigestion

Licorice root extract is often used to relieve symptoms of indigestion, such as acid reflux, upset stomach, and heartburn. In a 30-day study in 50 adults with indigestion, taking a 75-mg licorice capsule twice daily resulted in significant improvements in symptoms, compared with a placebo. Licorice root extract may also alleviate symptoms of gastroesophageal reflux disease (GERD), including acid reflux and heartburn. In an 8-week study in 58 adults with GERD, a low dose of glycyrrhetinic acid in combination with standard treatment resulted in significant improvements in symptoms. Another study in 58 adults with GERD noted that the daily use of licorice root was more effective at reducing symptoms over a 2-year period than commonly used antacids. While these results are promising, larger human studies are necessary.

May help treat peptic ulcers

Peptic ulcers are painful sores that develop in your stomach, lower esophagus, or small intestine. They’re commonly caused by inflammation resulting from H. pylori bacteria. Licorice root extract and its glycyrrhizin may help treat peptic ulcers. One study in mice found that licorice extract doses of 91 mg per pound (200 mg per kg) of body weight protected against these ulcers better than omeprazole, a common peptic ulcer medication. While more research is needed in humans, a 2-week study in 120 adults showed that consuming licorice extract in addition to a standard treatment significantly reduced the presence of H. pylori.

May have anticancer properties

Due to its content of numerous plant compounds with antioxidant and anti-inflammatory effects, licorice root extract has been studied for its protective effects against certain types of cancer. In particular, licorice extract and its compounds have been linked to slowing or preventing cell growth in skin, breast, colorectal, and prostate cancers.

As research is limited to test tubes and animals, its effects on human cancers are unknown. Yet, licorice root extract may help treat oral mucositis — very painful mouth sores that people with cancer sometimes experience as a side effect of chemotherapy and radiation. A 2-week study in 60 adults with head and neck cancer revealed that a topical licorice film was just as effective as the standard treatment for oral mucositis.

May ease upper respiratory conditions

Due to their anti-inflammatory and antimicrobial effects, both licorice root extract and tea may aid upper respiratory conditions. In particular, animal studies conclude that glycyrrhizin extract from licorice root helps relieve asthma, especially when added to modern asthma treatments. While limited human research shows similar results, more rigorous, long-term studies are needed. Additionally, limited test-tube and human studies suggest that licorice root tea and extract may protect against strep throat and prevent sore throat after surgery. Still, further research is needed.

May protect against cavities

Licorice root may help protect against bacteria that can lead to cavities. A 3-week study gave 66 preschool-aged kids sugar-free lollipops containing 15 mg of licorice root twice per day during the school week. Consuming the lollipops significantly reduced the number of Streptococcus mutans bacteria, which are the main cause of cavities.

Test-tube studies also show licorice root extract to be effective at protecting against bacteria commonly linked to cavities and tooth decay. However, more research is needed on the optimal dose and form of licorice root.

Licorice root extract is tied to several other potential benefits. It may:

Aid diabetes. In a 60-day study in rats, daily intake of licorice root extract resulted in significant improvements in blood sugar levels and kidney health. This effect has not been confirmed in humans.

Reduce menopause symptoms. Licorice root extract has been proposed as a treatment for hot flashes during menopause. However, the evidence on its effectiveness for this purpose is limited.

Boost weight loss. Some studies indicate that licorice root extract lowers body mass index (BMI) and supports weight loss. Yet, other studies have not found any effects on weight.

Help treat hepatitis C. One test-tube study noted that adding glycyrrhizin to a standard hepatitis C treatment significantly reduced the virus’s spread. While promising, these results have not been confirmed in humans.

Applications:

As a sweetener, licorice extract is used in the food industry;
2. As raw materials of drugs for clearing heat and detoxicating, licorice extract is used in the medical field;
3. As a product for benefiting the stomach, licorice extract is widely used in the health industry;
4. Licorice extract applied in cosmetic field, licorice extract is able to nourish and cure the skin.