Pure Natural Sapindus Mukurossi Extract Sapindoside 40% Soap Nut Extract CAS 95851-50-6

Product Description

                                                                  Quick Details

Product Description:

Sapindus japonica has been a commonly used detergent in my country since ancient times, especially for shampooing and face washing. Ancient and modern medical books have made detailed records on the washing and medical effects of Sapindus japonica. Li Shizhen's "Compendium of Materia Medica" in the Ming Dynasty described: Sapindus japonica shampoo can remove wind and brighten eyes, make hair bright and smooth, and face washing can whiten and remove freckles. Sapindus japonica is the only plant recorded in the "Compendium of Materia Medica" for shampooing and washing face. There are about 13 varieties of Sapindus japonica, which are distributed in Asia, America and Oceania. China is produced in the south of the Yangtze River Basin.

Sapindus japonica is a plant of the Sapinaceae family, and its rhizomes, bark, leaves, and fruits can be used as medicine. Sapindus japonica mainly contains saponin, fatty oil, protein and other components. Sapindus mucus is produced in hillside forests, and all provinces south of the Yangtze River are produced. Sapindus sinensis is flat in nature and bitter in taste. It has the functions of clearing heat, expectorating phlegm, eliminating accumulation and killing insects. Studies have shown that Sapindus japonica has a good therapeutic effect on viral hepatitis, Sapindus japonica has the effect of reducing mouse liver microsomal cytochrome P-450, and Sapindus japonica has antihypertensive and cardioprotective effects. Recent studies have shown that total saponins from Sapindus japonica have antibacterial, antioxidant, anti-myocardial ischemia and protective effects on ischemia-reperfusion injury.

Sapindus saponin is a natural non-ionic surfactant, which can reduce the surface tension of water, has rich foam, delicate hand feeling, strong detergency, antibacterial, environmental protection, pollution-free, rich foam, dirt removal, antibacterial beauty , Soft skin, whitening freckle, acne, prevention and treatment of skin diseases and other characteristics.

It can be used as an active ingredient to inhibit the activity of butyrate in the whitening lotion, and it can also be used as an active ingredient of natural active substances in natural shampoos and various skin care cosmetics. With the enhancement of people's awareness of environmental protection, the natural active substances extracted from Sapindus japonica have regained attention again, and many new washing products made of the combination of Sapindus japonica actives and synthetic actives are deeply loved by users. In addition to good foaming and decontamination properties, Sapindus japonica triterpenoid saponins have been proven to have antibacterial, bactericidal and anti-inflammatory effects on human skin, as well as dandruff and antipruritic effects.

1. Sapindus saponin has strong decontamination ability, is easily degradable, and has no harmful residues. It is easy and convenient to rinse, has no peculiar smell, and is less irritating to the skin. It can be used for skin cleaning (bathing, face washing, hand washing, shampooing), Washing clothes and cars, so it is an excellent raw material for shampoos, cosmetics and various biological detergents;

2. It has a strong effect of reducing surface tension, and has the functions of antibacterial beauty, sterilization and anti-inflammatory, anti-dandruff and anti-itching, freckle and acne-removing, whitening, and prevention and treatment of skin diseases on human skin;

3. Sapindus saponin is also a good pesticide emulsifier, and it has a good killing effect on cotton aphids, red spiders and sweet potato jinhua insects;

4. Sapindus saponin has various pharmacological effects such as anti-tumor, anti-virus, anti-fungal, and lowering blood pressure;

5. Sapindus saponin can significantly reduce the volume and concentration of gastric acid, so it has the potential to treat acute gastric ulcer;

6. In addition, Sapindus sapindii also contains many substances that are beneficial to the human body, such as: reducing sugars, fatty acids, oils, oleic acid, carotenoids, riboflavin, protein, vitamin C, vitamin A, vitamin B and More than 10 amino acids such as amino acid, tyrosine, phenylalanine, glutamic acid, glycine and histidine.

Physiological effect:

1. Bactericidal effect

The study found that ethanol and chloroform extracts of Sapindus japonica can inhibit the proliferation of Helicobacter pylori at very low concentrations (10 mg/mL in vitro and 2.5 mg/mL in vivo), and the Helicobacter pylori cultured for 10 consecutive generations. The bacteria also did not develop resistance to Sapindus japonica extract. Methanol extract of Sapindus japonica peel showed obvious antibacterial activity against two fungi (Rhizoctonia bataticola Briton Jones and Sclerotium rolfsii Sacc.) (ED50 ranged from 181 to 407 µg/mL), and they also found that sugar-free saponins had no antifungal activity. , the antifungal activity of disaccharide chain saponins was significantly stronger than that of monosaccharide chain saponins, indicating that sugar chain is a necessary condition for the antifungal activity of triterpenoid saponins. The in vitro antibacterial activity of the ethanol extract of Sapindus japonica fruit on Candida albicans found that it can cause cell wall deformation, cell lysis, cytoplasmic membrane rupture and other phenomena within 60 minutes, thus playing a bactericidal function. The total saponins of Sapindus japonica have good antibacterial activity against gram-negative bacteria, and the inhibitory effect on fungal growth is stronger than that on bacteria, in a dose-dependent manner. A bactericide is formulated with Sapindus sapindis and citrus fruit extracts, which can inhibit WHO gonococcus and Neisseria gonorrhoeae isolated from clinical acid and ciprofloxacin-resistant bacteria) and prevent HIV and HPV infection.

2. Anti-tumor effect

The methanol extract of Sapindus japonica peel has inhibitory activity on the proliferation of mouse melanoma B16F10, human cervical cancer HeLa and human gastric cancer MK-1 cells. The three types of tumor cells have the same degree of inhibition of proliferation, but the two saponins have no inhibitory activity at all, and the degree of inhibition of the proliferation of tumor cells by saponins is enhanced when the acetyl group binds to the sugar chain. The ethanol and n-hexane extracts of Sapindus japonica had strong anti-proliferation activities on cervical cancer HeLa and lung cancer A549 cell lines (IC50 ranged from 214.7 to 298.5 µg/mL). Oleanolic acid-type saponins isolated from n-butanol extract of Sapindus japonica fruit have moderate cytotoxic activity against human lung cancer A549, human breast cancer MDA-231 and human prostate cancer PC-3 cell lines. The total saponins of Sapindus japonica down-regulated the expression of bcl-2 gene in human lung cancer A549 cells, and then it was concluded that the mechanism of total saponins of Sapindus japonicas inhibiting the proliferation of A549 cancer cells might be the induction of apoptosis.

3. Protect stomach and liver

In addition to being used as a soap substitute in the United States, Sapindus mucus fruit is also used to treat inflammatory conditions such as skin lesions and ulcers; studies have shown that the fruit extract can reduce the amount of gastric secretions in pylorus-ligated mice, researchers speculate It may be that substances such as saponins and tannins play a role in fighting gastric ulcers. Studies have shown that Sapindus japonica extract has the ability to protect hepatocytes in vitro, and has repair function in vivo on carbon tetrachloride-induced liver damage in mice; Sapindus japonica ethanol extract can also regulate blood lipid levels and improve liver function in NAFLD rats. tissue pathological changes. Triterpene saponin compounds such as oleanolic acid derivatives and ivy saponins isolated from Sapindus genus have activity in preventing and treating ulcers. In vivo experiments, 20 mg/kg of Sapindoside B (Sapindoside B) reduced hepatic cytochrome P-450 in mice by 55%. 450, but this reduction basically disappeared after 3 d.

4. Other physiological effects

The antioxidant activity test of different solvent extracts of Sapindus japonicas showed that the water extract of Sapindus japonica fruit has the strongest antioxidant activity, and the methanol extract of Sapindus japonica leaves contains the highest total flavonoid content, and both observed The high redox potential was reached, showing the possibility of Sapindus japonica extract as health food and medicine. At the same time, the extract of Sapindus japonica and β-lactam antibiotics were given to experimental animals by oral or rectal administration. The concentration of antibiotics in blood is maintained above the minimum effective concentration for a long time. The acid-base hydrolyzate of sapindus saponin was studied in the laboratory on antifeeding and growth regulation of the pest Spodoptera litura. The results showed that the hydrolyzate of sapindusin can show significant antifeeding effect and toxicity to the third stage larvae. The study also showed that the saponin SMG-1 isolated from Sapindus muscaria could inhibit the binding of FMLP and the corresponding receptors, and it has the potential to be developed as a therapeutic agent for the treatment of neutrophilic inflammation.

Application:

1. Pharmaceutical field

Sapindus is a traditional Chinese herbal medicine in my country. Its medicinal value was recorded as early as in the Compendium of Materia Medica by Li Shizhen in the Ming Dynasty. Its roots and fruits can be used as medicine, which can clear heat and detoxify, resolve phlegm and relieve cough; flowers can treat eye diseases; seeds can prevent bad breath; peels can be used for Sore throat, cough and asthma, food stagnation, leucorrhea, chancre accumulation, sore ringworm, swollen poison, and prevent dandruff. Pharmacological studies in recent years have shown that the fruit of Sapindus japonica is rich in saponins and has various physiological activities such as antibacterial, antifungal, and antitumor.

2. Daily chemical field (shampoo)

Sapindus japonica extract (saponin) has strong surface activity and is a natural non-ionic surfactant. Its degreasing ability is better than that of commercially available detergents, and Sapindus japonica saponins are easily degradable and have no harmful residues. Afterwards, it will cause environmental pollution problems such as water pollution and environmental hormone residues. In addition, Sapindus saponin has a broad-spectrum elution effect on heavy metals, and the elution rate of lead, manganese, chromium, arsenic, mercury, etc. is more than 90%. In addition to its good decontamination effect, Sapindus also contains a variety of natural nutritional conditioning substances such as amino acids and vitamins. It has antibacterial, anti-inflammatory, anti-dandruff and antipruritic effects, and it is less irritating to the skin, safe and reliable. Adding Sapindus The shampoo of the extract has a better washing effect without the addition of a synthetic softener, and the hair is soft and shiny. Superior washing performance, good biodegradability, broad-spectrum antibacterial ability, and rich nutritional conditioning ingredients make Sapindus an inestimable potential in the development of environmentally friendly daily chemical products such as biological detergents and natural cosmetics.