CAS 531-95-3 Equol 98% White Fine Powder for Relieve Menopause Symptoms

Product Description

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Product description:

Equol comes from soy. When soy is eaten certain bacteria in the gut change chemicals contained in soy to equol. However, only 30-60% of people are able to break down soy chemicals to form equol. Some studies have shown that people capable of breaking soy down to form equol get more health benefits from soy. These people are called “equol producers.”

Equol is used for reducing menopause symptoms such as hot flashes in women. It is also used to prevent weak bones (osteoporosis) and to reduce wrinkled skin. Other uses include preventing metabolic syndrome, preventing diseases of the heart and blood vessels, treating high cholesterol, treating diabetes, and preventing breast and prostate cancer.

Equol comes in two different forms, R-equol or S-equol. Most commercial equol products contain S-equol.

The effect of equol on postmenopausal women

Considering the potential estrogenic effect of equol, it is expected to be beneficial for postmenopausal women as an alternative estrogen therapy. In a study of the effects of equol on perimenopausal/postmenopausal women, Ishiwata et al37) reported that 12 weeks of 30 mg/day S-equol supplement improved mood-related symptoms without any adverse effects in perimenopausal/ postmenopausal equol non-producers. Furthermore, according to Aso et al38) study, 10 mg/day of equol consumption for 12 weeks significantly reduced the symptoms of postmenopause (hot flashes and other menopausal symptoms) in postmenopausal Japanese women who were equol non-producers. These two reports suggest that equol could improve both physical and mental symptoms related to perimenopausal/ postmenopausal women.

Bone health is a major issue in the health of postmenopausal women. Tousen et al2) studied the effect of 6 mg/day and 10 mg/day of equol on bone markers and concluded that 10 mg/day equol contributes to bone health in equol non-producing postmenopausal women. Ishimi et al39) reviewed the significance of equol on bone health, and concluded that equol may contribute to prevent bone loss in early postmenopausal women. Furthermore, Oyama et al40) reported that S-equol supplementation may have beneficial effects on skin aging in postmenopausal women. Based on the accumulating evidence, equol may act as a selective estrogen receptor modulator to improve peri- or postmenopausal health disorders and to prevent bone loss in postmenopausal women. In these equol intervention studies, no adverse effects were reported. Although long-term intervention studies are needed, equol might be helpful in promoting postmenopausal health.

Metabolic syndrome. There is early evidence that S-equol might lower some of the health risks that make overweight men and women more likely to develop metabolic syndrome.

Reducing the risk of osteoporosis (weak bones). There is some evidence that taking S-equol might slow bone loss in women near or beyond menopause who cannot produce equol from soy.

Wrinkled skin. There is some evidence that S-equol can reduce crow's-feet wrinkles in postmenopausal women who are unable to produce equol from soy. The topical effects of equol as an anti-aging substance have been shown in different studies. The effects result from both molecular and structural changes to the skin. Equol can, for instance, lead to an increase in telomere length. As an antioxidant, equol can decrease the aging process by reducing damage caused by reactive oxygen species (ROS). It may also act as a protective anti-photoaging substance by inhibiting acute UVA- induced lipid peroxidation. In addition, equol may have a positive impact on epigenetic regulation. Equol's phytoestrogenic properties may also affect skin health. Reduction of dark circles and eye wrinkles after treatment with equol has been reported. Equol may also protect skin from damage by pollution due to its anti-oxidative and anti-inflammatory properties.

Each of the enantiomers and the racemic mixture of both enantiomers have different characteristics, bioavailabilities and molecular effects. According to one study, (RS)-equol provided the greatest overall improvement in skin health, especially when applied topically.

The role of Equol against baldness

One of the hormones that stimulates prostate growth and is responsible for hair loss in males is Dihydrotestosterone (DHT). In this context, Equol plays a very important role: this molecule, which is produced by our intestine when we eat soya, prevents testosterone from being transformed into DHT. With the advent of this compound, which was discovered twenty years ago during the research conducted by a group of researchers from Colorado State University, Brigham Young University and Cincinnati Children’s Hospital Medical Center, it was possible to make an enormous contribution to the research and development of hair loss treatments.