Food Grade Nicotinamide Mononucleotide Powder Health Supplements

Product Description

Food Grade Nicotinamide Mononucleotide (NMN) 99% White Powder Health Supplements

English name:beta-nicotinamide mononucleotide

English nickname:3-carbamoyl-1-[5-O-(hydroxyphosphinato)-beta-D-ribofuranosyl]pyridinium;

3-(Aminocarbonyl)-1-(5-O-phosphonato-beta-D-ribofuranosyl)pyridinium;

3-(aminocarbonyl)-1-(5-O-phosphono-beta-D-ribofuranosyl) ;

3-carbamoyl-1-(5-O-phosphonopentofuranosyl)pyridinium; coenzyme NMN;

β-Nicotinamide mononucleotide; Nicotinamide mononucleotide; NMN; inner salt; Pyridinium;

CAS No:1094-61-7

EINECS No:214-136-5

molecular formula:C11H15N2O8P

molecular weight:334.2192

InChI:InChI=1/C11H15N2O8P/c12-10(16)6-2-1-3-13(4-6)11-9(15)8(14)7(21-11)5-20-22(17,18)19/h1-4,7-9,11,14-15H,5H2,(H3-,12,16,17,18,19)/t7-,8-,9-,11-/m1/s1

Property description: its appearance is freeze-dried powder, soluble in water.

NMN is a precursor of NAD+

NAD+ is also known as coenzyme I, the full name of nicotinamide adenine dinucleotide, also known as nicotinic acid diphosphate, exists in every cell and participates in thousands of reactions. NAD+ is an important coenzyme in the tricarboxylic acid cycle, promoting the metabolism of sugar, fat, and amino acids, and participating in the synthesis of energy; NAD+ is also the only substrate for coenzyme I consuming enzymes (the only substrate for the DNA repair enzyme PARP, the only substrate for the longevity protein Sirtuins) Substrate, the only substrate for cyclic ADP ribose synthase CD38/157).

The significance of NMN on physical health

1. Substance and energy metabolism

After NMN enters the body and becomes NAD+, it plays an important role in energy and material metabolism. As far as the TCA cycle is concerned, the TCA cycle is the final metabolic pathway of the three major nutrients (carbohydrates, lipids, and amino acids) in the human body, and it is also the hub of the metabolic link between carbohydrates, lipids, and amino acids. Providing a large amount of energy to the organism is the energy hub of the organism. Coenzyme I (NAD) in mitochondria is reduced to reduced coenzyme I (NADH) by electron transfer in the TCA cycle. 1 mol of coenzyme I (NAD) can generate 3 mol of ATP, which is an important source of energy for cell life activities.

2. Prevent age-related physical decline

Numerous studies have confirmed that NAD+ levels in humans decrease with age. Mice supplemented with NMN show weight loss, increased energy, and better blood sugar control levels. NMN reverses the physiological effects of age. Sexual decline. While NAD+ depleting enzymes (PARP, cADPR, and Sirtuins) play important roles in biological processes of metabolism, inflammation, stress, and injury responses, and play an important role in cell cycle regulation and anti-aging. General research believes that the mechanism of NMN anti-aging is through the following three enzymes that utilize NAD+.

3. Improve type 2 diabetes

Type 2 diabetes is an epidemic in today's society, and research suggests that high calorie and sedentary times destroy our body's natural metabolism of sugar. One mechanism suggests that high-calorie food intake destroys NAD+ anabolism, and NMN supplementation increases insulin sensitivity and improves age-induced glucose intolerance.

4. Prevention of neurodegenerative diseases (Parkinson's, Alzheimer's)

Research now generally believes that axonal degeneration is the cause of neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease (AD), and amyotrophic lateral sclerosis. Multiple transcripts are induced following neuronal injury, including a more than 20-fold increase in NRK2, which catalyzes the synthesis of NAD+ in a compensatory response to increase NAD+ levels. Experiments have shown that NAD+ supplementation improves neuroprotection against traumatic brain injury, Parkinson’s, and amyotrophic lateral sclerosis, and neuromuscular normalization delays memory decline. Alzheimer’s disease exhibits reduced NAMPT and impaired neural stem cell differentiation, and after extremely high NAMPT activity or NAD+ supplementation, reduced β-amyloid content increases, via PGC-1α-mediated β-amyloid -Secretase (BACE1) degrades and induces mitochondrial biosynthesis to improve Alzheimer's disease.