Natural Organic Acorus Calamus Root Extract Powder
Contact Person : Jane Jiang
Phone Number : 86-13572180216
WhatsApp : +8613572180216
|Minimum Order Quantity :||25KG||Packaging Details :||Sample：1kg/bag with Polyethylene bag. Orders: Professional Drum with Net Weight 25kg|
|Delivery Time :||7-15 days||Payment Terms :||L/C, T/T|
|Supply Ability :||1000kg per month|
|Place of Origin:||CHINA||Brand Name:||HONGDA|
|Part:||Bark||Appearance:||White Fine Powder|
|Product Name:||Betula Alba Extract||Test Method:||HPLC|
|Application:||Health-care Products, Food Field, Pharmaceutical Products||Specification:||90% Betulin|
|Shelf Life:||2 Years||Color:||White|
|Latin Name:||Betula Platyphylla Suk.|
90% Betulin Betula Alba Extract,
CAS 473-98-3 Betula Alba Extract,
HPLC Betula Alba Extract
|Product name:||Betula Alba Extract|
Betula platyphylla Suk.
|Color:||White Fine Powder|
|Particle Size:||100% pass 80 mesh|
|Loss on drying:||≤5.00%|
|Acid insoluble Ash:||≤5.0%|
|Heavy metals(as Pb):||≤10ppm|
|Total microbacterial count:||NMT10000cfu/g|
|Total Yeast & Mold:||NMT1000cfu/g|
What is Betula platyphylla Suk.?
Deciduous tree, up to 25 meters high, with a straight trunk. White papery bark, shedding in layers regardless of the season; twigs thin; triangular-ovate leaves with irregularly serrated margins, 5-8 pairs of lateral veins, few hairy or glabrous; first leaves bloom, Unisexual, monoecious, catkins; cylindrical inflorescences solitary drooping; nuts small and flat, with broad wings on both sides, mature in autumn.
Distributed in Russia, Siberia, China, North Korea, Mongolia, Japan and other places.
White birch likes light and is hardy. It grows at an altitude of 400 meters to 4,100 meters and is found in broad-leaved deciduous forests, hillsides, forests and mixed coniferous and broad-leaved forests.
Betulin : CAS:473-98-3
Betulin is a lupin-type pentacyclic triterpenoid composed of 6 isoprenes. Molecular formula is C30H50O2, relative molecular mass 442.72, white crystalline powder, melting point 252-253℃, soluble in ethanol, ether, chloroform and benzene, slightly soluble in cold water, petroleum ether and other organic solvents. Lowit first reported the substance in birch bark in 1788 and isolated it.
Betulin is extracted from birch bark. Betulin has anti-inflammatory, anti-virus, inhibiting protein dissolution in hair fiber, improving damaged hair luster, promoting hair growth and other activities, and can be used in food, cosmetics and pharmaceutical industries.
Betulin has a wide range of biological activities. It has been verified by a variety of animal models and cell models. It can be known that betulin has the functions of expectorating phlegm and relieving cough, inhibiting melanin, lowering blood lipids, protecting liver and anti-cancer, anti-inflammatory, anti-viral, anti-tumor, and anti-inflammatory properties. HIV, improve functional properties such as Alzheimer's disease (AD).
1.Inhibit the formation of melanin
Betulin can be used as a natural, safe, and side-effect-free traditional Chinese medicine phytoestrogen. It inhibits melanin synthesis in A375 cells through the p38-MAPK signaling pathway, reduces skin hyperpigmentation, and improves the impact of chloasma on the appearance of patients. Affected by side effects, reduce the incidence of uterine cancer and breast cancer.
2. Lowering blood lipids
Betulin has good pharmacological effects in anti-hyperlipidemia, and can reduce blood cholesterol and triacylglycerol at the same time. In addition, it can also inhibit the function of cholesterol regulatory element binding protein (SREBP), thereby affecting the metabolism of cholesterol, significantly reducing the levels of triglycerides, fatty acids and cholesterol in the blood, and improving hyperlipidemia and insulin resistance in obese patients. The treatment effect of type diabetes is obvious.
3. Hepatoprotective effect
Betulin has a certain therapeutic effect on alcoholic fatty liver disease in rats. It can significantly improve the steatosis and necrosis of liver tissue caused by alcohol, inhibit the damage of alcohol-induced lipid peroxidation on liver tissue, and have a good effect on alcoholic liver disease. Injury has a better therapeutic effect.
4. Anti-cancer and anti-tumor effect
Betulin has been shown to inhibit several types of cancer cells, including RCC4, DLD-1, PC-3, HeLa, SK-HEP-1, HepG2, A549, and MCF-7 cells, as well as cervical cancer cell line. It promotes tumor cell apoptosis by inducing apoptosis-related mitochondrial pathways and exerts anti-tumor activity. Recently, some scholars found that betulin can inhibit the proliferation of gastric cancer MGC-803 cells and induce apoptosis, and its mechanism of action may be related to the inhibition of PI3K/AKT pathway activation.
5. Anti-inflammatory and antioxidant activity
Both betulin and betulinic acid are mildly anti-inflammatory at higher concentrations, and their anti-inflammatory properties may depend on the inhibition of protein kinase C without involving any neurogenic inflammatory mechanisms. Inflammation is closely related to various diseases, such as bacterial pneumonia, alcoholic lung injury, mammary gland inflammation, myocardial protection, mouse foot injury, etc. Betulin can reduce LPS-induced acute lung injury by inhibiting LPS and E. coli-induced pro-inflammatory factors, reducing myeloperoxidase activity and bacterial load in lung tissue.
Studies have shown that betulin has a certain therapeutic effect on radiation-injured mice, and its mechanism may be related to scavenging free radicals in the body; in addition, betulin has a protective effect on adriamycin-induced myocardial injury in rats, and its mechanism may be related to the Betulin inhibits oxidative stress-related.
The main component of birch bark, betulin, can derive powerful anti-HIV drugs and can be used as medicinal resources. The three mushroom substances in white birch mainly include betulin, betulinic acid, and lupeol. Most of these three compounds and their derivatives have anti-tumor and anti-inflammatory biological activities, and have inhibitory effects on protease and reverse transcriptase. Their scope of action affects almost every link of the virus life cycle, but most compounds focus on Virus adsorption stage. MarcPharmaceuticals Company in the United States has completed cell experiments data show that a new derivative of betulin can inhibit HIV-1 replication, and did not observe any toxic side effects on cell activity.
7. Protect hippocampal neurons
Betulin can improve the depressive behavior of chronic stress depression model rats, and has a certain protective effect on its hippocampal neurons. Betulin plays a role in protecting synapses by increasing the expressions of PSD-95 and Synapsin-I in the hippocampus, reducing the damage of oxidative stress on hippocampal neurons, and improving the learning and memory ability of APP/PS1 double transgenic dementia model mice The improvement effect, enhance the long-term hippocampus, and protect the cognitive function of experimental animals.
1. Pharmaceutical industry: Betulin is mainly used as a pharmaceutical intermediate, and betulin and its derivatives have shown great potential in HIV and cancer treatment as biological agents. At the same time, it is used to relieve cough and expectorant, treat allergic rhinitis, insomnia, depression, etc.
2. Food industry: There are studies using it as a preservative for meat products.
3. Cosmetics industry: Betulin has a strong anti-aging effect on the inhibition of collagenase activity and the proliferation of skin cells, which can be used to condition the skin, smooth the skin, and prevent chapped. It is also a good external penetration aid.
4. Daily chemical industry: In hair products, birch brain can reduce protein dissolution in hair fibers, improve the luster of damaged hair, and promote hair growth.