HPLC Pure Organic Ginseng Extract Powder PPT 98% (20S)-Protopanaxatriol CAS 34080-08-5

Product Description

                                                                 

Quick Details

Product name:	Ginseng Extract
Latin name:	Ginseng Radix et Rhizoma
Part Used:	Root
TEST METHOD:	HPLC
Color:	White Fine Powder
Odor:	Characteristic
density:	0.5-0.7g/ml
Particle Size:	100% pass 80 mesh
Loss on drying:	≤5.00%
Acid insoluble Ash:	≤5.0%
Heavy metals(as Pb):	≤10ppm
Lead(Pb):	≤2ppm
Arsenic (As):	≤2ppm
Residual Pesticide:	Negative
Total microbacterial count:	NMT10000cfu/g
Total Yeast & Mold:	NMT1000cfu/g
Salmonella:	Negative
E.Coli.	Negative

 

Product description:

Ginseng has been used in traditional Chinese medicine for centuries.

 

This slow-growing, short plant with fleshy roots can be classified three ways, depending on how long it is grown: fresh, white or red.

 

Fresh ginseng is harvested before 4 years, while white ginseng is harvested between 4–6 years and red ginseng is harvested after 6 or more years.

 

There are many types of this herb, but the most popular are American ginseng (Panax quinquefolius) and Asian ginseng.

 

American and Asian ginseng vary in their concentration of active compounds and effects on the body. It is believed that American ginseng works as a relaxing agent, whereas the Asian variety has an invigorating effect.

 

Ginseng contains two significant compounds: ginsenosides and gintonin. These compounds complement one another to provide health benefits.

What is Protopanaxatriol (PPT)?

Protopanaxatriol (PPT) is a metabolite of ginsenoside Rgl in the protopanaxatriol group. Ginsenoside Rgl is hydrolyzed by the action of intestinal microflora in the body to hydrolyze the glucose at position C-20 to obtain secondary ginsenoside Rhl. Glucose at the -6 position obtains secondary ginsenoside F1: then Rhl hydrolyzes the glucose at the C-6 position, and F1 hydrolyzes the glucose at the C-20 position. Finally, both Rhl and F1 are metabolized to generate PPT. Studies have shown that PPT has a strong biological Among them, it has a prominent role in cardiovascular protection. Studies have also found that PPT has anti-tumor, anti-fat synthesis and anti-diabetic effects.

 

The protopanaxatriol-type saponin Rg1 is metabolized by the human intestinal flora to form a transformation product by losing sugar residues. For the premise of PPT to exert its efficacy, some studies believe that pharmacokinetic studies can provide a theoretical basis for the efficacy and safety of compounds. KONG L et al. 9 studied the pharmacokinetics and oral bioavailability of PPT. The results showed that PPT was administered orally. It can be quickly absorbed into the body, the peak time Tmax is 0.58h, and the peak concentration Cmax is 0.13μg/mL, and the absolute bioavailability is 3.69%. Analysis suggests that the chemical instability of PPT in the stomach may be the reason for its low bioavailability. . Currently, LC-MS is the main method to determine the in vivo plasma concentration of PPT to verify its pharmacokinetic process110-1. A large number of studies have shown that PPT as a ginsenoside has strong biological activity, especially in cardiovascular protection.

Benefits of Ginseng

• Potent Antioxidant That May Reduce Inflammation

Ginseng has beneficial antioxidant and anti-inflammatory properties.

 

Some test-tube studies have shown that ginseng extracts and ginsenoside compounds could inhibit inflammation and increase antioxidant capacity in cells.

 

For example, one test-tube study found that Korean red ginseng extract reduced inflammation and improved antioxidant activity is skin cells from people with eczema.

 

The results are promising in humans, as well.

 

One study investigated the effects of having 18 young male athletes take 2 grams of Korean red ginseng extract three times per day for seven days.

 

The men then had levels of certain inflammatory markers tested after performing an exercise test. These levels were significantly lower than in the placebo group, lasting for up to 72 hours after testing.

 

However, it should be noted that the placebo group got a different medicinal herb, so these results should be taken with a grain of salt and more studies are needed.

 

Lastly, a larger study followed 71 postmenopausal women who took 3 grams of red ginseng or a placebo daily for 12 weeks. Antioxidant activity and oxidative stress markers were then measured.

 

Researchers concluded that red ginseng may help reduce oxidative stress by increasing antioxidant enzyme activities.

 

2. May Benefit Brain Function

Ginseng could help improve brain functions like memory, behavior and mood.

Some test-tube and animal studies show that components in ginseng, like ginsenosides and compound K, could protect the brain against damage caused by free radicals.

 

One study followed 30 healthy people who consumed 200 mg of Panax ginseng daily for four weeks. At the end of the study, they showed improvement in mental health, social functioning and mood.

 

However, these benefits stopped being significant after 8 weeks, suggesting that ginseng effects might decrease with extended use.

 

Another study examined how single doses of either 200 or 400 mg of Panax ginseng affected mental performance, mental fatigue and blood sugar levels in 30 healthy adults before and after a 10-minute mental test.

 

The 200-mg dose, as opposed to the 400-mg dose, was more effective at improving mental performance and fatigue during the test.

 

It is possible that ginseng assisted the uptake of blood sugar by cells, which could have enhanced performance and reduced mental fatigue. Yet it is not clear why the lower dose was more effective than the higher one.

 

A third study found that taking 400 mg of Panax ginseng daily for eight days improved calmness and math skills.

 

What’s more, other studies found positive effects on brain function and behavior in people with Alzheimer’s disease.

 

3. Could Improve Erectile Dysfunction

Research has shown that ginseng may be a useful alternative for the treatment of erectile dysfunction (ED) in men.

 

It seems that compounds in it may protect against oxidative stress in blood vessels and tissues in the penis and help restore normal function.

 

Additionally, studies have shown that ginseng may promote the production of nitric oxide, a compound that improves muscle relaxation in the penis and increases blood circulation.

 

One study found that men treated with Korean red ginseng had a 60% improvement in ED symptoms, compared to 30% improvement produced by a medication used to treat ED.

 

Moreover, another study showed that 86 men with ED had significant improvements in erectile function and overall satisfaction after taking 1,000 mg of aged ginseng extract for 8 weeks.

 

However, more studies are needed to draw definite conclusions about the effects of ginseng on ED.

 

4. May Boost the Immune System

Ginseng may strengthen the immune system.

 

Some studies exploring its effects on the immune system have focused on cancer patients undergoing surgery or chemotherapy treatment.

 

One study followed 39 people who were recovering from surgery for stomach cancer, treating them with 5,400 mg of ginseng daily for two years.

 

Interestingly, these people had significant improvements in immune functions and a lower recurrence of symptoms.

 

Another study examined the effect of red ginseng extract on immune system markers in people with advanced stomach cancer undergoing post-surgery chemotherapy.

 

After three months, those taking red ginseng extract had better immune system markers than those in the control or placebo group.

 

Furthermore, a study suggested that people who take ginseng could have up to a 35% higher chance of living disease-free for five years after curative surgery and up to a 38% higher survival rate compared to those not taking it.

 

It seems that ginseng extract could enhance the effect of vaccinations against diseases like influenza, as well.

 

Even though these studies show improvements in immune system markers in people with cancer, more research is needed to demonstrate the efficacy of ginseng in boosting resistance to infections in healthy people.

 

 

4. May Boost the Immune System

Ginseng may strengthen the immune system.

 

Some studies exploring its effects on the immune system have focused on cancer patients undergoing surgery or chemotherapy treatment.

 

One study followed 39 people who were recovering from surgery for stomach cancer, treating them with 5,400 mg of ginseng daily for two years.

 

Interestingly, these people had significant improvements in immune functions and a lower recurrence of symptoms.

 

Another study examined the effect of red ginseng extract on immune system markers in people with advanced stomach cancer undergoing post-surgery chemotherapy.

 

After three months, those taking red ginseng extract had better immune system markers than those in the control or placebo group.

 

Furthermore, a study suggested that people who take ginseng could have up to a 35% higher chance of living disease-free for five years after curative surgery and up to a 38% higher survival rate compared to those not taking it.

 

It seems that ginseng extract could enhance the effect of vaccinations against diseases like influenza, as well.

 

Even though these studies show improvements in immune system markers in people with cancer, more research is needed to demonstrate the efficacy of ginseng in boosting resistance to infections in healthy people.

 

6. May Fight Tiredness and Increase Energy Levels

Ginseng has been shown to help fight fatigue and promote energy.

 

Various animal studies have linked some components in ginseng, like polysaccharides and oligopeptides, with lower oxidative stress and higher energy production in cells, which could help fight fatigue.

 

One four-week study explored the effects of giving 1 or 2 grams of Panax ginseng or a placebo to 90 people with chronic fatigue.

 

Those given Panax ginseng experienced less physical and mental fatigue, as well as reductions in oxidative stress, than those taking the placebo.

 

Another study gave 364 cancer survivors experiencing fatigue 2,000 mg of American ginseng or a placebo. After eight weeks, those in the ginseng group had significantly lower fatigue levels than those in the placebo group.

 

Furthermore, a review of over 155 studies suggested that ginseng supplements may not only help reduce fatigue but also enhance physical activity.

 

7. Could Lower Blood Sugar

Ginseng seems to be beneficial in the control of blood glucose in people both with and without diabetes.

 

American and Asian ginseng have been shown to improve pancreatic cell function, boost insulin production and enhance the uptake of blood sugar in tissues.

 

Moreover, studies show that ginseng extracts help by providing antioxidant protection that reduce free radicals in the cells of those with diabetes.

 

One study assessed the effects of 6 grams of Korean red ginseng, along with the usual anti-diabetic medication or diet, in 19 people with type 2 diabetes.

 

Interestingly, they were able to maintain good blood sugar control throughout the 12-week study. They also had an 11% decrease in blood sugar levels, a 38% decrease in fasting insulin and a 33% increase in insulin sensitivity.

 

Another study showed that American ginseng helped improve blood sugar levels in 10 healthy people after they performed a sugary drink test.

 

It seems that fermented red ginseng could be even more effective at blood sugar control. Fermented ginseng is produced with the help of live bacteria that transform the ginsenosides into a more easily absorbed and potent form.

 

In fact, a study demonstrated that taking 2.7 grams of fermented red ginseng daily was effective at lowering blood sugar and increasing insulin levels after a test meal, compared to a placebo.

Application:

1. Ginseng extract is used in the medical and health care industry and can be formulated into anti-fatigue, anti-aging and

brain-healthy health foods;

2, ginseng extract is applied to the beauty and cosmetic industry, which can be formulated into ecchymosis, reduce wrinkles,

activate skin cells, and enhance skin elasticity;

3. Ginseng extract can also be used as a food additive, is used to make soaps, cosmetics, and as a flavoring in beverages.

Application dosage forms: suppositories, lotions, injections, tablets, capsules, and the like.