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HPLC Cosmetic Centella Asiatica Extract 95% Madecassoside CAS 34540-22-2

Minimum Order Quantity : 1kg Price : $24/kg~$100/kg
Packaging Details : 1kg: Sealed aluminum foil bags/25kg Paper Drum Delivery Time : 3 Days
Payment Terms : L/C, Western Union, MoneyGram, T/T Supply Ability : 10Ton/Month
Place of Origin: China Brand Name: HongdaPharma
Certification: ISO22000/KOSHER/HALAL/BRC Model Number: HC-206

Detail Information

Product Name: Centella Asiatica Extract Appearance: Powder
Color: Brown Yellow Source: Leaf
Latin Name: Centella Asiatica(L.) Urban Shelf Life: 2 Year
Particle Size: 80 Mesh
High Light:

Centella Asiatica Extract Madecassoside

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Cosmetic 95% Madecassoside Powder

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HPLC Gotu Kola Extract

Product Description

Cosmetic Ingredient Centella Asiatica Extract Madecassoside 95% CAS.34540-22-2 HPLC

 

Madecassoside has skin hydration properties. It is a well-known collagen inducer that exerts anti-aging and anti-rheumatoid arthritis effects. Madecassoside also elicits neuroprotective activities.

Madecassoside is a triterpenoid compound found in Centella Asiatica (Gotu kola), a medicinal herb used in traditional Chinese medicine (TCM), Ayurvedic medicine, and traditional African medicine. Madecassoside has a wide range of reported biological activities including, anti-inflammatory, wound healing, and anti-oxidant activities. It has been reported to suppress LPS-induced TNF-alpha production via inhibition of ERK, p38, and NF-kappaB activity.

HPLC Cosmetic Centella Asiatica Extract 95% Madecassoside CAS 34540-22-2 0

 

Chinese name 羟基积雪草苷
English name Madecassoside
English alias 6-deoxyhexopyranosyl-(1->4)hexopyranosyl-(1->6)-1-O-(2,3,6,23-tetrahydroxy-28-oxours-12-en-28-yl)hexopyranose
madecasoside
CAS 34540-22-2
EINECS 252-076-1
chemical formula C48H78O20
molecular weight 975.121
InChI InChI=1/C48H78O20/c1-19-10-11-48(13-12-46(6)22(28(48)20(19)2)8-9-27-44(4)14-24(52)39(61)45(5,18-50)38(44)23(51)15-47(27,46)7)43(62)68-42-35(59)32(56)30(54)26(66-42)17-63-40-36(60)33(57)37(25(16-49)65-40)67-41-34(58)31(55)29(53)21(3)64-41/h8,19-21,23-42,49-61H,9-18H2,1-7H3
density 1.47g/cm3
boiling point 1043.6°C at 760 mmHg
Flashpoint 295.8°C
vapor pressure 0mmHg at 25°C
refractive index 1.637

 

HPLC Cosmetic Centella Asiatica Extract 95% Madecassoside CAS 34540-22-2 1

Application of Centella Asiatica extract in cosmetics

 

1 Antibacterial activity of Centella Asiatica extract

 

Centella Asiatica extract contains asiatic acid and madecassolic acid, which are active saponins that acidify the cytoplasm in plant cells. This antimicrobial activity protects the plant itself against mold and yeast attacks. Experiments show that Centella Asiatica extract has a certain inhibitory effect on Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus acnes, etc., and there are reports in the folk that freshly washed Centella Asiatica is smashed and applied to the affected area to treat boils. Taking advantage of this feature, Centella Asiatica extract can be used to treat acne or in disposable hygiene products.

 

2 Anti-inflammatory activity of Centella Asiatica extract

 

Centella Asiatica extract can reduce the production of pro-inflammatory mediators (IL21, MMP21), and improve and repair the skin's own barrier function, thereby preventing and correcting skin immune dysfunction. Experiments show that the total glucosides of Centella Asiatica have an obvious anti-inflammatory effect. Centella Asiatica also has antibacterial and antiviral effects and has bacteriostatic effects on Staphylococcus aureus and Proteus. Centella Asiatica Extract has anti-inflammatory activity. Using this property of Centella Asiatica extract, we can use it in after-sun repair, anti-allergic and soothing cosmetics.

 

3 Centella Asiatica extract has the promotion effect of fibroblast and collagen synthesis

 

After more than 20 years of scientific research, it has been found that Centella Asiatica extract can promote the synthesis of collagen I and III, as well as the secretion of mucopolysaccharides (such as the synthesis of hyaluronic acid), increase skin water retention, and activate and renew skin cells. , soothes, enhances, and radiates the skin; on the other hand, through the cDNA array test, it is also found that Centella Asiatica extract also has the activation effect of fibroblast gene, which can enhance the vitality of skin basal cells, maintain skin elasticity and Firming feeling, smooth facial fine wrinkles.

It was also found through experiments that after the application of different doses of asiaticoside and madecassoside to the cultured fibroblasts in vitro, the type I procollagen amino acids in the supernatant of the experimental group and the blank control group were determined by radioimmunoassay. The content of protelopeptide (PINP) and type III procollagen aminotelopeptide (PIIINP).

The results show:

①Compared with the blank control group, madecassoside and madecassoside can effectively stimulate the secretion of HSFbPⅠNP and PⅢNP in vitro;

②The biological effects of asiaticoside and madecassoside in stimulating the secretion of PINP and PIIINP from target cells showed an obvious dose-effect relationship;

③In the dose of 10μg/mL~150μg/mL, Ad showed stronger biological activity than Md on HSFb-stimulated PINP secretion (P<0.01). Experiments show that Centella Asiatica extract can significantly promote the synthesis of fibroblasts and collagen.

 

Bayer conducted a double-blind human test on 40 female volunteers with stretch marks. The experimental protocol: an oil/water/oil formulation containing 1% Centella Asiatica extract was applied twice a day for 3 months.

 

At the same time, the company's related tests also showed that Centella Asiatica extract can speed up the repair process of scars, shorten the healing time by 40%; can also prevent stretch marks during pregnancy. 3.4 Other effects of Centella Asiatica extract also have a strong antioxidant effect, which can inhibit free radical activity, dilute melanin deposition, improve skin blood circulation, renew skin cell regeneration, and help melanin metabolize smoothly out of the body. After use, the skin is smooth, delicate, white, and bright.

 

To sum up, Centella Asiatica extract, a unique "plant collagen", can have various effects such as antibacterial and anti-inflammatory, and promote the synthesis of collagen and fibroblasts. Healing, scar repair (including stretch mark removal products), anti-wrinkle, anti-aging, acne removal, breast shaping, and other personal care products have broad market prospects.

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