Pure Organic DIM Diindolylmethane / 3,3'-Diindolylmethane Powder CAS 1968-05-4
Contact Person : Jane Jiang
Phone Number : 86-13572180216
WhatsApp : +8613572180216
|Minimum Order Quantity :||1kg||Price :||$24/kg~$100/kg|
|Packaging Details :||1kg: Sealed aluminum foil bags/25kg Paper Drum||Delivery Time :||3 Days|
|Payment Terms :||L/C, Western Union, MoneyGram, T/T||Supply Ability :||10Ton/Month|
|Place of Origin:||China||Brand Name:||HongdaPharma|
|Product Name:||Pomegranate Peel Extract 40% Ellagic Acid||Appearance:||Powder|
|Color:||Brown||Shelf Life:||2 Year|
|Particle Size:||80 Mesh||Grade Standard:||Food Grade|
|Latin Name:||Pericarpium Granati|
Pomegranate Peel Extract Ellagic Acid,
Natural Pomegranate Peel Powder,
Scavenge Free Radicals Pomegranate Extract Powder
Natural Organic Pomegranate Peel Extract 70% Ellagic Acid Scavenge Free Radicals
Certificate Of Analysis
|Product Name||Pomegranate peel extract|
|Latin Name||Punica granatum Linn|
|Type of extraction||Water|
|Sieve Analysis||95% pass 80 mesh|
|Moisture Content||NMT 5.0%|
|Arsenic (As)||NMT 2ppm|
|Lead (Pb)||NMT 2ppm|
|Heavy Metals||20ppm max|
|Total Plate Count||10,000cfu/gMax|
|Salmonella||Negative in 25 g|
|Yeast & Mold||1000cfu/gMax|
|Staphylococcus Aureus||Negative in 25 g|
Ellagic acid is a natural supplement developed in the laboratory by HCI (Hollings Cancer Institute) led by Dr. Daniel Nixon for nine years. Studies have shown that ellagic acid can effectively inhibit the growth and spread of cancer cells within 48 hours and kill cancer cells within 72 hours. The report also pointed out that ellagic acid exhibits G-Arrest (tumor cell apoptosis) in papilloma of the cervix, and ellagitannins (Ellagitannins) can decompose blood cancer cells. Ellagic acid can protect normal cells against carcinogenic toxins caused by tobacco nicotine, food additives, and chemical toxicity, protect cell membranes, and prevent cell degeneration. It is the guardian of the human body. European medical research reports pointed out that ellagitannins extracted from cranberries can promote wound healing, prevent heart disease, reduce the formation of liver cysts, and have antibacterial and antiviral effects.
At the same time, it is also one of the effective whitening ingredients recognized by dermatology medicine. It is a polyphenolic molecule, which is widely found in many kinds of plants and fruits in nature. For skin whitening, it inhibits tyrosinase activity, blocks melanin production, and has the effect of whitening and fading. In addition, ellagic acid can effectively protect from external damage. Blocks tyrosinase activity, inhibits melanin production and has antioxidant effects. That is to say, it is very excellent in shutting down the melanin pigment production reaction in melanin-producing cells, and has an antioxidant effect.
Ellagic acid has various biologically active functions, such as antioxidant function, anticancer, antimutagenic properties, and inhibitory effect on the human immunodeficiency virus. In addition, ellagic acid is also an effective coagulant, which has a good inhibitory effect on a variety of bacteria and viruses and can protect the wound from the invasion of bacteria, prevent infection, and inhibit ulcers. At the same time, studies have found that ellagic acid also has antihypertensive and sedative effects.
1. Scavenge free radicals
Since the 1950s, the antioxidant properties of ellagic acid in the human body and in vitro have been continuously explored and studied, and more and more research results have shown that ellagic acid has strong scavenging free radicals and antioxidant capacity. Ellagic acid has a scavenging effect on oxygen free radicals and hydroxyl radicals, and its ability to scavenge free radicals is higher than that of antioxidants such as sesame oil, olive leaf extract, and lutein.
2. Inhibit lipid peroxidation
In terms of inhibiting lipid peroxidation, ellagic acid is considered to be the most effective inhibitor of the initial stage of microsomal NADPH-dependent lipid peroxidation, and ellagic acid can also strongly inhibit lipid peroxidation induced by doxorubicin. Ellagic acid inhibits ferromyoglobin/hydrogen peroxide-dependent lipid peroxidation. Ellagic acid can block lipid peroxidation (LPO) induced by foreign substances in T cells, inhibit the generation of reactive oxygen species (ROS), and improve cell death caused by cytotoxicity.
3. Other antioxidant activities
Ellagic acid reduces cellular damage caused by radiation, hydrogen peroxide, and mitomycin C in mouse bone marrow cells. Ellagic acid effectively inhibits the oxidation of DCDHF induced by per nitrite as well as the oxidation of per nitrite itself. At the same time, ellagic acid prevented per nitrite-induced single-strand breaks and nitration of tyrosyl groups in bovine serum albumin in TZ 18U plasmid DNA. Thus, in vitro, ellagic acid protects biomolecules from per nitrite-induced oxidative and nitrative damage.
The activation of pancreatic astrocytes is an important cause of pancreatic fibrosis, acute pancreatitis, and other diseases. Ellagic acid inhibits interleukin 1b (IL-1) and tumor necrosis factor-α (TNF-α)-induced activin-1 and mitogen-activated protein kinase activities, thereby inhibiting nascent pancreatic astrocyte transformation for the activated fibroblastic phenotype. Ellagic acid, as a secondary metabolite, exerts anti-eosinophilic activity in a β-glucan peritonitis model. Ellagic acid is a potent inhibitor of eosinophils and can be used to treat allergic inflammation. Ellagic acid can resist carbon tetrachloride-induced hepatotoxicity and lipid peroxidation induced by tert-butyl hydroperoxide both in vivo and in vitro, so it has a protective effect on the liver.
Melanocytes are present in the basal layer of the epidermis, where melanin is produced. The raw material for melanin production is tyrosine, which must be converted into dopa (DOPA) and dopaquinine (DOPAquinine) successively by tyrosinase, and finally, melanin is formed. Ellagic acid blocks the production of melanin by inhibiting the activity of tyrosinase.
Therefore, high-purity ellagic acid is mainly used as additives in medicines, health foods, and cosmetics, as functional factors such as anti-oxidation, inhibition of human immunodeficiency virus, and skin whitening.